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Chemotherapy was potentiated by E7449 and one agent had important antitumor activity in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile traces, very likely by TNKS inhibition. In step with this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and drastically al